Treatment Recommendations for Major Depression Associated with Menopause Depression during perimenopause and menopause is treated in much the same way as depression that strikes at any other time. Two types of psychotherapy are highly recommended for depression related to menopause. Interpersonal therapy focuses on understanding how changing human relationships may contribute to, or relieve, depression. Cognitive-behavorial therapy focuses on identifying and changing the pessimistic thoughts and beliefs that accompany depression. Psychotherapy is usually combined with medication in major depression.		“Anxiety often manifests as a physical symptom like pain, fatigue, or inability to sleep, so it’s not surprising that one out of five patients who come to a doctor’s office with a physical complaint have anxiety.” Kurt Kroenke, M.D.